Disease Modeling

Organoids are human stem cell or adult tissue-derived in vitro 3D organ models and allow the study of biological processes, such as cell behavior, tissue repair, and response to drugs or mutations, in an environment miming endogenous cell organization and organ structures. Organoids are significant technological breakthroughs from the beginning and are now firmly established as an essential tool in biological research and have important implications for clinical use. Organoids have shown potential in modeling diseases, gene editing, and transplantations. Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many aspects of the complex structure and function of the corresponding in vivo tissue. These organoids can be dissected and interrogated for fundamental mechanistic studies on development, regeneration, and repair in human tissues and can be used in diagnostics, drug discovery, and personalized medicine.

We can do the following organoid model system from human induced pluripotent stem cells (HiPSCs) or patient-specific HiPSCs:

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  • Intestinal Organoids: HiPSCs-derived intestinal organoids consisting of villi (enterocytes, goblet, and enteroendocrine cells) and crypt structures.
  • Cerebral Organoids: Cortical layers of neurons, mature synaptic neurons, and neural network.
  • Choroid Plexus: Choroid plexus consisting of secretory epithelium and cerebrospinal fluids for testing central nervous system (CNS) drug permeability.
  • CNS mimics brain Organoids: Brain organoids containing microglia, astrocytes, and epithelial and endothelial cells.
  • Brain organoid with vascularization
  • 3D-based Immune System: Dendritic cells, macrophages, and other immune cells in matrices.
  • Alveolar Organoids
  • Hepatic Organoids
  • Kidney Organoids
  • Book a consultation if you need a specific organoid model system not listed here.

 

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if you need a specific molecular biology assay for your drug or chemical screening, but it is not listed here Contact Us.