Drug And Toxicity Screening

Toxicity testing is a vital step in developing and approving chemical compounds for clinical trials and use for humans. However, current model systems often fail to predict human toxicity in vivo. Animal models cannot recapitulate human in vivo complexity, contributing to over 90% of the drug failure rate today. The complexity of three-dimensional (3D) human organ-like organoid cell culture systems can generate potentially more relevant human physiology and disease models, including toxicity predictions. NeyroblastGX patent pending 3D spheroids or organoid technology mimics human in vivo system and can screen toxicity in higher sensitivity and specificity. NeyroblastGX scientists developed various culture methods from 2D to 3D and organoid systems to screen drugs, chemicals, toxins, and pathogens without batch-to-batch variation with higher reproducibility

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2D Culture:

Any cell lines, including neuronal and epithelial cell lines from grow to produce cellular toxicity assay such as MTT assay (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide), NRU assay (neutral red uptake assay), LDH test (Lactate Dehydrogenase), AlamarBlue and CellTiter-Blue cell viability assay. We also can provide assays with rapid high-throughput electroconductive screening methods using ECIS plates (Applied Biophysics Inc.).

3D Culture:

3D spheroids and organoids are NeyroblastGX core technology. We can custom-made organoids or spheroids as your project interest and provide toxicity screens of drugs, chemicals, toxins, and pathogens with higher reproducibility. We have set up various assays using 3D spheroids and organoids. So book a consultation for your needs.

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if you need a specific molecular biology assay for your drug or chemical screening, but it is not listed here Contact Us.

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